2 Timothy 4:16
16At my first defense, no one came to help me, but all left me. May it not be held against them.
At the first defense—Wesley: before the savage emperor Nero—no one stood by him; all deserted. Wesley: my friends and companions forsook me; and do we expect to find such as will not forsake us? Yet: May it not be held against them.
Desertion hurts, and pardon is offered. Paul will not bind their cowardice to them as a final verdict. Grace toward the weak is not blindness about Demas (v. 10); it is a gospel reflex: some failed in a crisis and are still to be spared the charge, if they will return under mercy.
Calvin will note that even if the Roman church failed its duty, the gospel suffered no loss. Paul’s prayer—May it not be held against them—echoes a cruciform mercy.
God can keep the apostle when the church does not show up. Forgiveness is requested for those whose courage failed, which is different from blessing Alexander’s opposition (vv. 14–15). The Lord remains the one who stands when people do not.